Gambart M, Breinig S, Breton A, Vial J, Herbault-Barres B, Bouali O
Service de réanimation pédiatrique, hôpital des Enfants de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France.
Arch Pediatr. 2012 Sep;19(9):927-31. doi: 10.1016/j.arcped.2012.06.010. Epub 2012 Aug 9.
Lactobezoar is a compact mass of undigested milk concretions and mucous secretions in the gastrointestinal tract. It is usually located in the stomach, resulting in various degrees of gastric outlet obstruction. Lactobezoar is the most common type of bezoar in infancy. We report the case of rare and complicated gastric outlet obstruction secondary to lactobezoar. A female infant, 35weeks and 4days' gestation, one of dichorionic, diamniotic twins (birth weight, 1.890kg), was referred to our center at 5days of life for shock and food intolerance. She was on discontinuous oral feedings with a maltodextrin-enriched infant formula. On examination on day 4, there was a tender mass palpable in the left hypochondrium and on day 5, there was abdominal distension with signs of hemodynamic instability and sepsis. Plain abdominal X-ray showed a pneumoperitoneum associated with a heterogeneous mass in a distended stomach, consistent with a bezoar. An emergency laparotomy revealed a gastric perforation secondary to a large lactobezoar, with necrosis of the greater curvature and anterior wall of the stomach. Surgical treatment consisted of extraction of the lactobezoar, partial gastrectomy (resection of necrotic areas), and gastrostomy. Pathological examination confirmed the necrosis of the gastric mucosa. The postoperative course was complicated by prolonged sepsis. The child was kept NPO for 21days. On day 21 postsurgery, an upper gastrointestinal contrast study showed a well-dimensioned stomach, with a good pyloric passage. Gastrostomy and oral feedings were then initiated with good outcome at 6months. Etiopathogenic factors of lactobezoar are prematurity, low birth weight, altered gastric secretions and disturbed gastric emptying, hypercaloric and predominantly casein-based formulas, and inadequate milk composition. Lactobezoar should be considered in infants with symptoms of gastrointestinal obstruction with evocative images. Conservative management with nil per os, parenteral nutrition, and regular saline gastric washes has a good prognosis with rapid resolution of symptoms. Surgical indications are rare, and early and appropriate diagnosis should help limit and reduce the morbidity of lactobezoar.
乳石是胃肠道内未消化的乳凝块和黏液分泌物形成的紧密团块。它通常位于胃内,导致不同程度的胃出口梗阻。乳石是婴儿期最常见的胃石类型。我们报告一例罕见且复杂的继发于乳石的胃出口梗阻病例。一名孕35周零4天的女婴,双绒毛膜双羊膜囊双胞胎之一(出生体重1.890千克),出生5天时因休克和食物不耐受被转诊至我院。她间断口服富含麦芽糊精的婴儿配方奶。第4天检查时,左季肋部可触及压痛性肿块,第5天出现腹胀,伴有血流动力学不稳定和脓毒症体征。腹部平片显示气腹,扩张的胃内有不均匀肿块,符合胃石表现。急诊剖腹探查发现一枚大乳石继发胃穿孔,胃大弯和前壁坏死。手术治疗包括取出乳石、部分胃切除术(切除坏死区域)和胃造口术。病理检查证实胃黏膜坏死。术后病程因脓毒症持续时间长而复杂。患儿禁食21天。术后第21天,上消化道造影显示胃形态正常,幽门通道良好。随后开始胃造口喂养和经口喂养,6个月时效果良好。乳石的病因包括早产、低出生体重、胃分泌物改变和胃排空障碍、高热量且主要基于酪蛋白的配方奶以及牛奶成分不足。对于有胃肠道梗阻症状且影像学表现提示的婴儿应考虑乳石。禁食、肠外营养和定期用生理盐水洗胃的保守治疗预后良好,症状可迅速缓解。手术指征罕见,早期且恰当的诊断有助于限制和降低乳石的发病率。