HSPIR：一个人工标注的热休克蛋白信息资源。
HSPIR: a manually annotated heat shock protein information resource.
机构信息
Department of Biochemistry, Indian Institute of Science, Bangalore 560012, Karnataka, India.
出版信息
Bioinformatics. 2012 Nov 1;28(21):2853-5. doi: 10.1093/bioinformatics/bts520. Epub 2012 Aug 24.
SUMMARY
Heat shock protein information resource (HSPIR) is a concerted database of six major heat shock proteins (HSPs), namely, Hsp70, Hsp40, Hsp60, Hsp90, Hsp100 and small HSP. The HSPs are essential for the survival of all living organisms, as they protect the conformations of proteins on exposure to various stress conditions. They are a highly conserved group of proteins involved in diverse physiological functions, including de novo folding, disaggregation and protein trafficking. Moreover, their critical role in the control of disease progression made them a prime target of research. Presently, limited information is available on HSPs in reference to their identification and structural classification across genera. To that extent, HSPIR provides manually curated information on sequence, structure, classification, ontology, domain organization, localization and possible biological functions extracted from UniProt, GenBank, Protein Data Bank and the literature. The database offers interactive search with incorporated tools, which enhances the analysis. HSPIR is a reliable resource for researchers exploring structure, function and evolution of HSPs.
AVAILABILITY
摘要
热休克蛋白信息资源 (HSPIR) 是六个主要热休克蛋白 (HSP) 的协同数据库，即 Hsp70、Hsp40、Hsp60、Hsp90、Hsp100 和小 HSP。这些 HSP 对于所有生物的生存都是必不可少的，因为它们在暴露于各种应激条件下保护蛋白质的构象。它们是一组高度保守的蛋白质，参与多种生理功能，包括从头折叠、解聚和蛋白质运输。此外，它们在控制疾病进展中的关键作用使它们成为研究的主要目标。目前，关于 HSP 在跨属识别和结构分类方面的信息有限。在这种情况下，HSPIR 提供了来自 UniProt、GenBank、蛋白质数据库和文献中提取的序列、结构、分类、本体论、结构域组织、定位和可能生物学功能的人工策展信息。该数据库提供了带有内置工具的交互式搜索，可增强分析。HSPIR 是探索 HSP 结构、功能和进化的研究人员的可靠资源。
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