HIV 的 T 细胞免疫应答
The T-cell response to HIV.
机构信息
Ragon Institute of MGH, MIT, and Harvard Mass General Hospital-East, Charlestown, Massachusetts 02129, USA.
出版信息
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a007054. doi: 10.1101/cshperspect.a007054.
Abstract
HIV is a disease in which the original clinical observations of severe opportunistic infections gave the first clues regarding the underlying pathology, namely that HIV is essentially an infection of the immune system. HIV infects and deletes CD4(+) T cells that normally coordinate the adaptive T- and B-cell response to defend against intracellular pathogens. The immune defect is immediate and profound: At the time of acute infection with an AIDS virus, typically more than half of the gut-associated CD4(+) T cells are depleted, leaving a damaged immune system to contend with a life-long infection.
摘要
HIV 是一种疾病，其中严重机会性感染的最初临床观察为潜在病理学提供了第一个线索，即 HIV 本质上是免疫系统的感染。HIV 感染并删除了正常协调适应性 T 细胞和 B 细胞反应以抵御细胞内病原体的 CD4(+)T 细胞。免疫缺陷是即时且深刻的：在急性感染艾滋病病毒时，通常超过一半的肠道相关 CD4(+)T 细胞被消耗殆尽，留下受损的免疫系统来应对终身感染。
相似文献
1
The T-cell response to HIV.
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a007054. doi: 10.1101/cshperspect.a007054.
2
Aspects of immunopathogenic mechanisms of HIV infection.
SADJ. 2007 Nov;62(10):432-4, 436.
3
CD8+ T-cells: function and response to HIV infection.
Curr HIV Res. 2004 Jan;2(1):23-37. doi: 10.2174/1570162043485077.
4
Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy.
Cell Death Differ. 2005 Aug;12 Suppl 1:859-70. doi: 10.1038/sj.cdd.4401595.
5
Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect.
Gastroenterology. 2010 Oct;139(4):1289-300. doi: 10.1053/j.gastro.2010.06.065. Epub 2010 Jun 27.
6
Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Edinburgh Heterosexual Transmission Study Group.
Lancet. 1996 Sep 7;348(9028):649-54. doi: 10.1016/s0140-6736(96)02091-0.
7
Fully immunocompetent CD8+ T lymphocytes are present in autologous haematopoietic stem cell transplantation recipients despite an ineffectual T-helper response.
PLoS One. 2008;3(10):e3616. doi: 10.1371/journal.pone.0003616. Epub 2008 Oct 31.
8
Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation.
AIDS Res Hum Retroviruses. 2012 Aug;28(8):789-92. doi: 10.1089/AID.2011.0145.
9
Cellular immune responses to HIV.
Nature. 2001 Apr 19;410(6831):980-7. doi: 10.1038/35073658.
10
Cytotoxic CD4 T-cells during HIV infection: Targets or weapons?
J Clin Virol. 2019 Oct;119:17-23. doi: 10.1016/j.jcv.2019.08.004. Epub 2019 Aug 16.
引用本文的文献
1
CPSF6 promotes HIV-1 preintegration complex function.
J Virol. 2025 May 20;99(5):e0049025. doi: 10.1128/jvi.00490-25. Epub 2025 Apr 9.
2
Natural Resistance to HIV Infection: Role of Immune Activation.
Immun Inflamm Dis. 2025 Feb;13(2):e70138. doi: 10.1002/iid3.70138.
3
A binary trait model reveals the fitness effects of HIV-1 escape from T cell responses.
Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2405379122. doi: 10.1073/pnas.2405379122. Epub 2025 Feb 19.
4
Cigarette smoke alters circRNA expression in human T-cells.
F1000Res. 2025 Apr 9;12:566. doi: 10.12688/f1000research.130430.2. eCollection 2023.
5
Involvement of Human Cellular Proteins and Structures in Realization of the HIV Life Cycle: A Comprehensive Review, 2024.
Viruses. 2024 Oct 29;16(11):1682. doi: 10.3390/v16111682.
6
Evaluation of the mindray CL900i CLIA HIV Ag/Ab combo assay for sensitive and specific HIV screening compared to established methods.
Sci Rep. 2024 Nov 15;14(1):28177. doi: 10.1038/s41598-024-78271-z.
7
Cyclophilin A facilitates HIV-1 integration.
J Virol. 2024 Nov 19;98(11):e0094724. doi: 10.1128/jvi.00947-24. Epub 2024 Oct 31.
8
The Intersection of HIV and Pulmonary Vascular Health: From HIV Evolution to Vascular Cell Types to Disease Mechanisms.
J Vasc Dis. 2024 Jun;3(2):174-200. doi: 10.3390/jvd3020015. Epub 2024 May 6.
9
Immune perturbation following SHIV infection is greater in newborn macaques than in infants.
JCI Insight. 2024 Aug 27;9(19):e144448. doi: 10.1172/jci.insight.144448.
10
Rapid intra-host diversification and evolution of SARS-CoV-2 in advanced HIV infection.
Nat Commun. 2024 Aug 22;15(1):7240. doi: 10.1038/s41467-024-51539-8.
本文引用的文献
1
HIV transmission.
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a006965. doi: 10.1101/cshperspect.a006965.
2
Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection.
J Infect Dis. 2011 Sep 1;204(5):768-76. doi: 10.1093/infdis/jir394.
3
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11530-5. doi: 10.1073/pnas.1105315108. Epub 2011 Jun 20.
4
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine.
Nature. 2011 May 26;473(7348):523-7. doi: 10.1038/nature10003. Epub 2011 May 11.
5
Differential microRNA regulation of HLA-C expression and its association with HIV control.
Nature. 2011 Apr 28;472(7344):495-8. doi: 10.1038/nature09914. Epub 2011 Apr 17.
6
Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.
PLoS Pathog. 2011 Feb 10;7(2):e1001273. doi: 10.1371/journal.ppat.1001273.
7
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.
J Virol. 2011 Apr;85(8):3996-4006. doi: 10.1128/JVI.02520-10. Epub 2011 Feb 2.
8
Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.
J Virol. 2011 Apr;85(7):3507-16. doi: 10.1128/JVI.02444-10. Epub 2011 Jan 26.
9
Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
J Infect Dis. 2011 Mar 15;203(6):803-9. doi: 10.1093/infdis/jiq122. Epub 2011 Jan 21.
10
Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers.
J Virol. 2011 Mar;85(6):3015-9. doi: 10.1128/JVI.01846-10. Epub 2010 Dec 22.
Zotero 插件