甲状腺与衰老过程；有哪些新进展？
The thyroid gland and the process of aging; what is new?
作者信息
Gesing Adam, Lewiński Andrzej, Karbownik-Lewińska Małgorzata
机构信息
Department of Oncological Endocrinology, Medical University of Lodz, Zeligowski St,, No, 7/9, Lodz, 90-752, Poland.
出版信息
Thyroid Res. 2012 Nov 24;5(1):16. doi: 10.1186/1756-6614-5-16.
The endocrine system and particular endocrine organs, including the thyroid, undergo important functional changes during aging. The prevalence of thyroid disorders increases with age and numerous morphological and physiological changes of the thyroid gland during the process of aging are well-known. It is to be stressed that the clinical course of thyroid diseases in the elderly differs essentially from that observed in younger individuals, because symptoms are more subtle and are often attributed to normal aging. Subclinical hypo- and hyperthyroidism, as well as thyroid neoplasms, require special attention in elderly subjects. Intriguingly, decreased thyroid function, as well as thyrotropin (TSH) levels - progressively shifting to higher values with age - may contribute to the increased lifespan.This short review focuses on recent findings concerning the alterations in thyroid function during aging, including these which may potentially lead to extended longevity, both in humans and animals.
内分泌系统尤其是内分泌器官，包括甲状腺，在衰老过程中会发生重要的功能变化。甲状腺疾病的患病率随年龄增长而增加，并且在衰老过程中甲状腺的许多形态和生理变化是众所周知的。需要强调的是，老年人甲状腺疾病的临床过程与年轻人有本质区别，因为症状更隐匿，且常被归因于正常衰老。亚临床甲状腺功能减退和亢进以及甲状腺肿瘤在老年人群中需要特别关注。有趣的是，甲状腺功能以及促甲状腺激素（TSH）水平随年龄增长逐渐升高，可能有助于延长寿命。这篇简短的综述聚焦于衰老过程中甲状腺功能改变的最新研究发现，包括那些可能潜在导致人类和动物寿命延长的发现。
Zotero 插件