细胞组织纤维化的机制。1. 与组织纤维化相关的常见机制和器官特异性机制。
Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis.
机构信息
Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany.
出版信息
Am J Physiol Cell Physiol. 2013 Feb 1;304(3):C216-25. doi: 10.1152/ajpcell.00328.2012. Epub 2012 Dec 19.
Abstract
Fibrosis is a pathological scarring process that leads to destruction of organ architecture and impairment of organ function. Chronic loss of organ function in most organs, including bone marrow, heart, intestine, kidney, liver, lung, and skin, is associated with fibrosis, contributing to an estimated one third of natural deaths worldwide. Effective therapies to prevent or to even reverse existing fibrotic lesions are not yet available in any organ. There is hope that an understanding of common fibrosis pathways will lead to development of antifibrotic therapies that are effective in all of these tissues in the future. Here we review common and organ-specific pathways of tissue fibrosis.
摘要
纤维化是一种病理性瘢痕形成过程，导致器官结构破坏和器官功能障碍。包括骨髓、心脏、肠道、肾脏、肝脏、肺和皮肤在内的大多数器官的慢性器官功能丧失都与纤维化有关，这导致了全球约三分之一的自然死亡。目前，在任何器官中，都没有有效的治疗方法来预防甚至逆转现有的纤维化病变。人们希望对共同的纤维化途径的理解将导致未来开发出对所有这些组织都有效的抗纤维化治疗方法。在这里，我们回顾了组织纤维化的常见和器官特异性途径。
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