Campins Magda, Moreno-Pérez David, Gil-de Miguel Angel, González-Romo Fernando, Moraga-Llop Fernando A, Arístegui-Fernández Javier, Goncé-Mellgren Anna, Bayas José M, Salleras-Sanmartí Lluís
Sociedad Española de Medicina Preventiva, Salud Pública e Higiene, Spain.
Enferm Infecc Microbiol Clin. 2013 Apr;31(4):240-53. doi: 10.1016/j.eimc.2012.12.011. Epub 2013 Feb 12.
A large increase of pertussis incidence has been observed in recent years in countries with high vaccination coverage. Outbreaks of pertussis are increasingly being reported. The age presentation has a bipolar distribution: infants younger 6months that have not initiated or completed a vaccination schedule, and adolescents and adults, due to the lost of natural or vaccine immunity over time. These epidemiological changes justify the need to adopt new vaccination strategies in order to protect young infants and to reduce pertussis incidence in all age groups. Adolescents and adults immunization must be a priority. In the first group, strategy is easy to implement, and with a very low additional cost (to replace dT vaccine by dTap one). Adult vaccination may be more difficult to implement; dT vaccine decennial booster should be replaced by dTap. The immunization of household contacts of newborn infants (cocooning) is the strategy that has a most important impact on infant pertussis. Recently, pregnant women vaccination (after 20weeks of gestation) has been recommended in some countries as the most effective way to protect the newborn.
近年来,在疫苗接种覆盖率高的国家,百日咳发病率大幅上升。百日咳疫情的报告越来越多。发病年龄呈两极分布:6个月以下未开始或未完成疫苗接种程序的婴儿,以及青少年和成年人,这是由于随着时间推移自然免疫或疫苗免疫丧失所致。这些流行病学变化表明有必要采取新的疫苗接种策略,以保护幼儿并降低所有年龄组的百日咳发病率。青少年和成人免疫接种必须成为优先事项。对于第一组人群,策略易于实施,且额外成本非常低(用无细胞百白破疫苗替代吸附百白破疫苗)。成人疫苗接种可能更难实施;应将吸附百白破疫苗的十年一次加强接种改为无细胞百白破疫苗。对新生儿家庭接触者进行免疫接种(围产期免疫)是对婴儿百日咳影响最大的策略。最近,一些国家建议在妊娠20周后对孕妇进行疫苗接种,作为保护新生儿的最有效方法。