神经母细胞瘤：发育生物学、癌症基因组学和免疫疗法。
Neuroblastoma: developmental biology, cancer genomics and immunotherapy.
机构信息
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Nat Rev Cancer. 2013 Jun;13(6):397-411. doi: 10.1038/nrc3526.
Abstract
Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained to developing risk-based therapies and, ultimately, improving outcome. In this Review we discuss the key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma, as well as new translational tools for bringing these promising scientific advances into the clinic.
摘要
神经母细胞瘤是一种起源于发育中的交感神经系统的实体瘤。在过去的十年中，我们对这种疾病的认识有了巨大的进展。未来的挑战是将所获得的知识应用于开发基于风险的治疗方法，并最终改善预后。在这篇综述中，我们讨论了神经母细胞瘤在发育生物学、分子遗传学和免疫学方面的关键发现，以及将这些有前途的科学进展转化为临床应用的新转化工具。
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