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基于纳米递药制剂独特性质的创新药物研发。

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation.

机构信息

CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, No. 11, First North Road, Beijing100190, P. R. China.

University of Chinese Academy of Science, Beijing, P. R. China.

出版信息

Nanoscale. 2013 Sep 21;5(18):8307-8325. doi: 10.1039/c3nr01525d.

Abstract

The advent of nanotechnology has reignited interest in the field of pharmaceutical science for the development of nanomedicine. Nanomedicinal formulations are nanometer-sized carrier materials designed for increasing the drug tissue bioavailability, thereby improving the treatment of systemically applied chemotherapeutic drugs. Nanomedicine is a new approach to deliver the pharmaceuticals through different routes of administration with safer and more effective therapies compared to conventional methods. To date, various kinds of nanomaterials have been developed over the years to make delivery systems more effective for the treatment of various diseases. Even though nanomaterials have significant advantages due to their unique nanoscale properties, there are still significant challenges in the improvement and development of nanoformulations with composites and other materials. Here in this review, we highlight the nanomedicinal formulations aiming to improve the balance between the efficacy and the toxicity of therapeutic interventions through different routes of administration and how to design nanomedicine for safer and more effective ways to improve the treatment quality. We also emphasize the environmental and health prospects of nanomaterials for human health care.

摘要

纳米技术的出现重新激发了人们对制药科学领域的兴趣,以开发纳米医学。纳米药物制剂是纳米级载体材料,旨在提高药物的组织生物利用度,从而改善系统应用化疗药物的治疗效果。与传统方法相比,纳米医学是一种通过不同给药途径输送药物的新方法,具有更安全、更有效的治疗效果。迄今为止,多年来已经开发出各种纳米材料来使给药系统更有效地治疗各种疾病。尽管纳米材料由于其独特的纳米级特性具有显著的优势,但在改进和开发具有复合材料和其他材料的纳米制剂方面仍存在重大挑战。在这篇综述中,我们重点介绍了纳米药物制剂,旨在通过不同的给药途径提高治疗干预的疗效和毒性之间的平衡,并探讨如何设计纳米药物以更安全、更有效的方式提高治疗质量。我们还强调了纳米材料对人类健康护理的环境和健康前景。

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