去阻遏转移特性导致能够高效传播编码碳青霉烯酶 OXA-48 的质粒。
Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48.
机构信息
INSERM U914, Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2014;58(1):467-71. doi: 10.1128/AAC.01344-13. Epub 2013 Nov 4.
Abstract
The current emergence of the carbapenemase OXA-48 among Enterobacteriaceae is related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors the blaOXA-48 gene within a composite transposon, Tn1999, which is inserted into the tir gene, encoding a transfer inhibition protein. We showed that the insertion of Tn1999 into the tir gene was involved in a higher transfer frequency of plasmid pOXA-48a. This may likely be the key factor for the successful dissemination of this plasmid.
摘要
目前肠杆菌科中产碳青霉烯酶 OXA-48 的出现与单个 IncL/M 型质粒 pOXA-48a 的传播有关。该质粒在 Tn1999 复合转座子内携带 blaOXA-48 基因，该转座子插入到编码转移抑制蛋白的 tir 基因中。我们表明，Tn1999 插入到 tir 基因中与质粒 pOXA-48a 更高的转移频率有关。这可能是该质粒成功传播的关键因素。
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