HIV 感染患者中的随机命运选择。
Stochastic fate selection in HIV-infected patients.
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
出版信息
Cell. 2013 Oct 24;155(3):497-9. doi: 10.1016/j.cell.2013.09.039.
PMID:24243007
Abstract
Classic studies proposed that stochastic variability ("noise") can drive biological fate switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from dormant (latently infected) patient cells-the major barrier to an HIV cure-is inherently stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require inventive approaches.
摘要
经典研究提出，随机变异性（“噪声”）可以驱动生物命运转换，提高进化成功率。现在，何等人报告称，HIV 从休眠（潜伏感染）患者细胞中重新激活 - 这是 HIV 治愈的主要障碍 - 本质上是随机的。消除不完全可诱导（概率）病毒表型将需要创新方法。
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