预先使用氯诺昔康对下颌第三磨牙手术后的镇痛效果。
Efficacy of preemptive lornoxicam on postoperative analgesia after surgical removal of mandibular third molars.
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Associate Professor, Anesthesiology and Reanimation Specialist, Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jan;117(1):27-31. doi: 10.1016/j.oooo.2013.08.027.
OBJECTIVE
Pain is the most encountered complication following third molar surgery. Although nonsteroidal anti-inflammatory drugs are often used for pain control, the effect of preemptive lornoxicam has not been detailed. We compare the analgesic efficacy of preemptive lornoxicam versus postoperative lornoxicam.
STUDY DESIGN
Forty-three participants aged 18 to 33 years who had bilateral, symmetrical third molars were included in this double-blind, randomized, placebo-controlled study. All participants took part in each of the 2 groups for a 1-month interval (crossover design). Group Pre received lornoxicam 8 mg intravenously 25 minutes before surgery and 2 mL serum saline postoperatively. Group Post was given the opposite protocol. Pain was evaluated by visual analog scale in the first 12 hours.
RESULTS
We observed statistically significant differences in the reduction of the pain level in group Pre (P < .05). These participants felt less pain in the first 5 postoperative hours and needed fewer analgesics in the first 12 postoperative hours.
CONCLUSIONS
Preemptive lornoxicam is effective for postoperative pain control.
目的
疼痛是第三磨牙手术后最常见的并发症。尽管非甾体抗炎药常用于止痛，但预先使用氯诺昔康的效果尚未详细说明。我们比较了预先使用氯诺昔康与术后使用氯诺昔康的镇痛效果。
研究设计
本双盲、随机、安慰剂对照研究纳入了 43 名年龄在 18 至 33 岁、双侧第三磨牙对称的参与者。所有参与者均在每个 2 组中各参加 1 个月的间隔（交叉设计）。Pre 组在手术前 25 分钟静脉注射氯诺昔康 8 毫克，术后给予 2 毫升生理盐水。Post 组则采用相反的方案。在最初的 12 小时内通过视觉模拟评分法评估疼痛。
结果
我们观察到 Pre 组在降低疼痛水平方面有统计学上的显著差异（P <.05）。这些参与者在术后的前 5 小时内感觉疼痛减轻，在术后的前 12 小时内需要的镇痛药较少。
结论
预先使用氯诺昔康对术后疼痛控制有效。
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