日本水杨梅活性成分对缺血心脏冠状动脉血管系统的重建作用。

Reconstitution of coronary vasculature by an active fraction of Geum japonicum in ischemic hearts.

作者信息

Chen Hao, Cheng Lei, Lin Xiaoli, Zhou Xiaping, Cai Zhiming, Li Ming

机构信息

1] The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, PR China [2] Joint Laboratory For Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

Joint Laboratory For Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

出版信息

Sci Rep. 2014 Feb 4;4:3962. doi: 10.1038/srep03962.

DOI:10.1038/srep03962

PMID:24492623

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3912486/

Abstract

Chronic coronary heart disease (cCHD) is characterized by atherosclerosis, which progressively narrows the coronary artery lumen and impairs myocardial blood flow. Restoration of occluded coronary vessels with newly formed collaterals remains an ideal therapeutic approach due to the need for redirecting blood flow into the ischemic heart. In this study, we investigated the effect of an active fraction isolated from Geum joponicum (AFGJ) on angiogenesis in cCHD hearts. Our results demonstrated that AFGJ not only enhanced capillary tube formation of endothelial cells, but also promoted the growth of new coronary collaterals (at the diameter 0.021-0.21 mm) in the ischemic region of hearts in rat cCHD model. Our study also indicated that the growth of new collaterals in ischemic hearts resulted in improved functional recovery of the cCHD hearts as demonstrated by ECG and echocardiography analyses. These data suggest that AFGJ may provide a novel therapeutic method for effective treatment of cCHD.

摘要

慢性冠心病（cCHD）的特征是动脉粥样硬化，它会使冠状动脉管腔逐渐变窄并损害心肌血流。由于需要将血流重新导向缺血心脏，利用新形成的侧支血管恢复闭塞的冠状动脉仍然是一种理想的治疗方法。在本研究中，我们研究了从柔毛水杨梅中分离出的活性成分（AFGJ）对cCHD心脏血管生成的影响。我们的结果表明，AFGJ不仅增强了内皮细胞的毛细血管管腔形成，还促进了大鼠cCHD模型心脏缺血区域新的冠状动脉侧支（直径0.021 - 0.21毫米）的生长。我们的研究还表明，缺血心脏中新侧支的生长导致cCHD心脏的功能恢复得到改善，心电图和超声心动图分析证明了这一点。这些数据表明，AFGJ可能为有效治疗cCHD提供一种新的治疗方法。