通过将光氧化还原催化与亲核催化相结合实现N-芳基四氢异喹啉的直接sp(3)C-H丙烯醛化反应。
Direct sp(3)C-H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis.
作者信息
Feng Zhu-Jia, Xuan Jun, Xia Xu-Dong, Ding Wei, Guo Wei, Chen Jia-Rong, Zou You-Quan, Lu Liang-Qiu, Xiao Wen-Jing
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
出版信息
Org Biomol Chem. 2014 Apr 7;12(13):2037-40. doi: 10.1039/c3ob42453g. Epub 2014 Feb 20.
Sequence catalysis merging photoredox catalysis (PC) and nucleophilic catalysis (NC) has been realized for the direct sp(3) C-H acroleination of N-aryl-tetrahydroisoquinoline (THIQ). The reaction was performed under very mild conditions and afforded products in 50-91% yields. A catalytic asymmetric variant was proved to be successful with moderate enantioselectivities (up to 83 : 17 er).
已实现将光氧化还原催化（PC）和亲核催化（NC）相结合的序列催化，用于N-芳基-四氢异喹啉（THIQ）的直接sp(3) C-H丙烯酰化反应。该反应在非常温和的条件下进行，产率为50-91%。催化不对称变体被证明是成功的，对映选择性适中（高达83:17的对映体过量）。
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