糖尿病与认知障碍之间的关系。
Relationships between diabetes and cognitive impairment.
作者信息
de la Monte Suzanne M
机构信息
Department of Pathology (Neuropathology), Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurosurgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
出版信息
Endocrinol Metab Clin North Am. 2014 Mar;43(1):245-67. doi: 10.1016/j.ecl.2013.09.006. Epub 2013 Dec 12.
Epidemics of obesity, diabetes, nonalcoholic fatty liver disease, and cognitive impairment/Alzheimer disease have emerged over the past 3 to 4 decades. These diseases share in common target-organ insulin resistance with a constellation of molecular and biochemical abnormalities that lead to organ/tissue degeneration over time. This article discusses the fundamental links among these diseases and how peripheral organ insulin resistance diseases contribute to cognitive impairment and neurodegeneration. A future role of endocrinologists and diabetologists could be to provide integrative diagnostic and treatment approaches for this collection of diseases that seem to share pathophysiological and pathogenetic bases.
在过去三四十年里，肥胖、糖尿病、非酒精性脂肪性肝病以及认知障碍/阿尔茨海默病的流行情况日益凸显。这些疾病都存在共同的靶器官胰岛素抵抗，并伴有一系列分子和生化异常，随着时间推移会导致器官/组织退化。本文将探讨这些疾病之间的根本联系，以及外周器官胰岛素抵抗疾病如何导致认知障碍和神经退行性变。内分泌学家和糖尿病学家未来的一个作用可能是为这一系列似乎具有共同病理生理和发病基础的疾病提供综合诊断和治疗方法。
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