野外消防员的动脉僵硬度、氧化应激和烟雾暴露情况。
Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters.
作者信息
Gaughan Denise M, Siegel Paul D, Hughes Michael D, Chang Chiung-Yu, Law Brandon F, Campbell Corey R, Richards Jennifer C, Kales Stefanos F, Chertok Marcia, Kobzik Lester, Nguyen Phuong-son, O'Donnell Carl R, Kiefer Max, Wagner Gregory R, Christiani David C
机构信息
Department of Preventive Medicine and the Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts.
出版信息
Am J Ind Med. 2014 Jul;57(7):748-56. doi: 10.1002/ajim.22331. Epub 2014 Jun 6.
OBJECTIVES
To assess the association between exposure, oxidative stress, symptoms, and cardiorespiratory function in wildland firefighters.
METHODS
We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8-iso-prostaglandin F2α (8-isoprostane) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and the smoke exposure marker (urinary levoglucosan). Arterial stiffness was assessed by examining levels of the aortic augmentation index, expressed as a percentage. An oxidative stress score comprising the average of z-scores created for 8-OHdG and 8-isoprostane was calculated.
RESULTS
Mean augmentation index % was higher for participants with higher oxidative stress scores after adjusting for smoking status. Specifically for every one unit increase in oxidative stress score the augmentation index % increased 10.5% (95% CI: 2.5, 18.5%). Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity.
CONCLUSIONS
Biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters.
目的
评估野外消防员的暴露、氧化应激、症状与心肺功能之间的关联。
方法
我们通过问卷调查、用于评估动脉僵硬度的脉搏波分析、肺活量测定、尿8-异前列腺素F2α（8-异前列腺素）和8-羟基-2'-脱氧鸟苷（8-OHdG）以及烟雾暴露标志物（尿左旋葡聚糖）对两支跨部门热射病急救小组进行了研究。通过检查以百分比表示的主动脉增强指数水平来评估动脉僵硬度。计算了一个氧化应激评分，该评分由为8-OHdG和8-异前列腺素创建的z分数的平均值组成。
结果
在调整吸烟状态后，氧化应激评分较高的参与者的平均增强指数百分比更高。具体而言，氧化应激评分每增加一个单位，增强指数百分比就增加10.5%（95%置信区间：2.5，18.5%）。较高的平均下呼吸道症状评分与一秒用力呼气量/用力肺活量预测百分比降低有关。
结论
氧化应激生物标志物可能作为野外消防员动脉僵硬度的指标。
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