新型水杨醛衍生物作为氰离子的荧光开启传感器。
Novel salicylaldehyde derivatives as fluorescence turn-on sensors for cyanide ion.
机构信息
Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand.
Organic Synthesis Unit, Department of Chemistry, Faculty of Science and Nanotec-CU Center of Excellence on Food and Agriculture Chulalongkorn University, Bangkok 10330, Thailand.
出版信息
J Hazard Mater. 2014 Sep 15;280:458-63. doi: 10.1016/j.jhazmat.2014.08.028. Epub 2014 Aug 27.
A novel series of fluorescent probes containing diphenylacetylene as fluorogenic units and salicylaldehyde as a CN(-) receptor were successfully synthesized by using sonogashira coupling. In the presence of Triton-X 100 non-ionic surfactant, the fluorophores exhibited fluorescence "turn-on" in response to CN(-) in aqueous media with the detection limit of 1.6 μM. The turn-on signal is the result of the conversion of the aldehyde to cyanohydrin via the internal acid catalyzed addition of cyanide. Using paper sensor strips, a naked eye detection of cyanide is possible down to 5 nmol.
成功合成了一系列新型荧光探针，这些探针含有二苯乙炔作为荧光基团，水杨醛作为 CN（-）受体，通过 Sonogashira 偶联反应得到。在 Triton-X 100 非离子表面活性剂存在的情况下，荧光团在水介质中对 CN（-）表现出荧光“开启”响应，检测限为 1.6 μM。开启信号是通过内部酸催化氰化物加成将醛转化为氰醇的结果。使用纸传感器条，可以实现对氰化物的肉眼检测，检测限低至 5 nmol。
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