甲型禽流感（H7N9）病毒的大流行潜力。
Pandemic potential of avian influenza A (H7N9) viruses.
作者信息
Watanabe Tokiko, Watanabe Shinji, Maher Eileen A, Neumann Gabriele, Kawaoka Yoshihiro
机构信息
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA; ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan; Laboratory of Veterinary Microbiology, Department of Veterinary Sciences, University of Miyazaki, Miyazaki, 889-2192, Japan.
出版信息
Trends Microbiol. 2014 Nov;22(11):623-31. doi: 10.1016/j.tim.2014.08.008. Epub 2014 Sep 25.
Avian influenza viruses rarely infect humans, but the recently emerged avian H7N9 influenza viruses have caused sporadic infections in humans in China, resulting in 440 confirmed cases with 122 fatalities as of 16 May 2014. In addition, epidemiologic surveys suggest that there have been asymptomatic or mild human infections with H7N9 viruses. These viruses replicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess mammalian-adapting amino acid changes that likely contribute to their ability to infect mammals. In this review, we summarize the characteristic features of the novel H7N9 viruses and assess their pandemic potential.
禽流感病毒很少感染人类，但最近出现的禽H7N9流感病毒已在中国导致人类散发病例，截至2014年5月16日，确诊病例达440例，其中122人死亡。此外，流行病学调查表明，存在H7N9病毒的无症状或轻症人类感染情况。这些病毒在哺乳动物中能高效复制，在雪貂和豚鼠中显示出有限的传播能力，并且具有可能有助于其感染哺乳动物能力的适应哺乳动物的氨基酸变化。在本综述中，我们总结了新型H7N9病毒的特征并评估了它们的大流行潜力。
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