母亲铅暴露与子代先天性心脏缺陷发生风险
Maternal lead exposure and risk of congenital heart defects occurrence in offspring.
作者信息
Liu Zhen, Yu Yu, Li Xiaohong, Wu Aimin, Mu Mingdao, Li Nana, Deng Ying, Jin Xi, Li Shengli, Lin Yuan, Chen Xinlin, Wang Fudi, Zhu Jun
机构信息
National Centre for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Department of Nutrition, Research Center for Nutrition and Health, Institute of Nutrition and Food Safety, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Public Health, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
出版信息
Reprod Toxicol. 2015 Jan;51:1-6. doi: 10.1016/j.reprotox.2014.11.002. Epub 2014 Nov 11.
Maternal lead exposure may be harmful to fetal development. However, sufficient evidence was lacked about the risk on cardiac development in offspring. To explore the association between maternal lead exposure and risks of congenital heart defects (CHDs) occurrence in fetuses, a case-control study was adopted during pregnant women making antenatal examinations. The maternal hair lead levels were measured by using inductively coupled plasma mass spectrometry (ICP-MS), and logistic regression analysis was used to calculate the odds ratio (OR). Three hundred and sixteen cases and 348 controls were eligible to the study. The median level of lead in maternal hair of case (0.670ng/mg) was significantly higher (AOR 3.07, 95% CI 2.00-4.72) than that of the control (0.461ng/mg), including the CHD cases with or without extracardiac malformations (AOR 3.55, 2.94, respectively). Maternal lead exposure is associated with the risk of some subtypes of CHDs occurrence in offspring. The potential dose-response relationship is also presented.
母体铅暴露可能对胎儿发育有害。然而，关于其对后代心脏发育风险的证据尚不充分。为探讨母体铅暴露与胎儿先天性心脏病（CHD）发生风险之间的关联，在进行产前检查的孕妇中开展了一项病例对照研究。采用电感耦合等离子体质谱法（ICP-MS）测定母体头发中的铅含量，并使用逻辑回归分析计算比值比（OR）。316例病例和348例对照符合研究条件。病例组母体头发铅含量中位数（0.670ng/mg）显著高于对照组（0.461ng/mg）（调整后比值比3.07，95%可信区间2.00-4.72），包括伴有或不伴有心外畸形的CHD病例（调整后比值比分别为3.55和2.94）。母体铅暴露与后代某些CHD亚型的发生风险相关。同时还呈现了潜在的剂量反应关系。
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