产前补充L-精氨酸和抗氧化剂对新生儿氧化应激标志物水平的影响。
The effect of antenatal L-arginine and antioxidant supplementation on oxidative stress marker levels in newborns.
作者信息
Dr Shweta, Khanna Anuradha
机构信息
Assistant Professor, MGMCRI , Pondicherry, India .
Professor, Institute of Medical Sciences , Bhu, Varanasi, India .
出版信息
J Clin Diagn Res. 2014 Oct;8(10):OC10-2. doi: 10.7860/JCDR/2014/8343.4966. Epub 2014 Oct 20.
INTRODUCTION
The present study was conducted in the Department of Obstetrics, Paediatrics & Biophysics IMS, BHU, Varanasi with an aim to study the role of L-arginine and oral antioxidants as a part of therapy in patients diagnosed with IUGR (Intra uterine growth restriction ) and cord serum NO and oxidative stress markers GSH and SOD in newborns following delivery of such patients.
MATERIALS AND METHODS
The study included 40 pregnant patient between 30-32 weeks of gestation diagnosed with IUGR who were divided into 3 groups: Group I (treated with L-arginine N=10), Group II (treated with antioxidants N=10), Group III (without nutritional supplementation N=10) and Group IV (healthy control pregnant patients of same gestational age range N=10) were taken. Cord serum NO & oxidative stress markers (GSH & SOD) were measured following delivery of patients from those four groups.
RESULTS
The cord serum NO levels (μmol/lt) showed a significant increase & SOD (U/ml) & GSH (U/lt) values were increased in newborns to mothers diagnosed with IUGR after treatment with L-arginine. Similar results were obtained for treatment with antioxidants.
CONCLUSION
The reduced NO & reduced cord serum circulating levels of oxidative stress markers (GSH & SOD) activity may play an important role in the occurrence of IUGR.
引言
本研究在瓦拉纳西贝拿勒斯印度教大学医学院妇产科、儿科学与生物物理学系开展，旨在研究L-精氨酸和口服抗氧化剂作为治疗手段的一部分，对诊断为宫内生长受限（IUGR）患者的作用，以及此类患者分娩后新生儿脐带血中的一氧化氮（NO）和氧化应激标志物谷胱甘肽（GSH）及超氧化物歧化酶（SOD）情况。
材料与方法
该研究纳入了40名妊娠30 - 32周、诊断为IUGR的孕妇，她们被分为3组：第一组（用L-精氨酸治疗，N = 10），第二组（用抗氧化剂治疗，N = 10），第三组（不进行营养补充，N = 10），并选取了第四组（相同孕周范围的健康对照孕妇，N = 10）。在这四组患者分娩后，测量其脐带血中的NO及氧化应激标志物（GSH和SOD）。
结果
L-精氨酸治疗后，诊断为IUGR的孕妇所产新生儿的脐带血NO水平（μmol/lt）显著升高，超氧化物歧化酶（U/ml）及谷胱甘肽（U/lt）值也升高。抗氧化剂治疗也获得了类似结果。
结论
NO减少以及脐带血中氧化应激标志物（GSH和SOD）活性的循环水平降低可能在IUGR的发生中起重要作用。
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