癌症治疗反应的微环境调节
Microenvironmental regulation of therapeutic response in cancer.
作者信息
Klemm Florian, Joyce Johanna A
机构信息
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Trends Cell Biol. 2015 Apr;25(4):198-213. doi: 10.1016/j.tcb.2014.11.006. Epub 2014 Dec 22.
Abstract
The tumor microenvironment (TME) not only plays a pivotal role during cancer progression and metastasis but also has profound effects on therapeutic efficacy. In the case of microenvironment-mediated resistance this can involve an intrinsic response, including the co-option of pre-existing structural elements and signaling networks, or an acquired response of the tumor stroma following the therapeutic insult. Alternatively, in other contexts, the TME has a multifaceted ability to enhance therapeutic efficacy. This review examines recent advances in our understanding of the contribution of the TME during cancer therapy and discusses key concepts that may be amenable to therapeutic intervention.
摘要
肿瘤微环境（TME）不仅在癌症进展和转移过程中起关键作用，而且对治疗效果也有深远影响。在微环境介导的耐药情况下，这可能涉及一种内在反应，包括对预先存在的结构元件和信号网络的利用，或者是肿瘤基质在治疗损伤后的获得性反应。或者，在其他情况下，TME具有多方面增强治疗效果的能力。本综述探讨了我们对TME在癌症治疗中的作用的最新认识进展，并讨论了可能适合进行治疗干预的关键概念。
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