老年人的端粒长度与下丘脑-垂体-肾上腺轴对应激的反应
Telomere length and hypothalamic-pituitary-adrenal axis response to stress in elderly adults.
作者信息
Savolainen Katri, Eriksson Johan G, Kajantie Eero, Lahti Jari, Räikkönen Katri
机构信息
Institute of Behavioural Sciences, University of Helsinki, PO Box 9, 00014 Helsinki, Finland.
Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, PO Box 30, 00271 Helsinki, Finland; Folkhälsan Research Centre, Haartmansgatan 8, 00290 Helsingfors, Finland; Vasa Central Hospital, Hietalahdenkatu 2-4, 65130 Vaasa, Finland; Department of General Practice and Primary Health Care, University of Helsinki, PO Box 20, 00014 Helsinki, Finland.
出版信息
Psychoneuroendocrinology. 2015 Mar;53:179-84. doi: 10.1016/j.psyneuen.2014.12.020. Epub 2015 Jan 6.
OBJECTIVE
Telomere shortening, a biomarker of cellular aging, has been associated with aging-related diseases. While psychological stress has been implicated in the process of telomere shortening, associations with activity of physiological stress systems have remained elusive. We studied whether leukocyte telomere length (LTL) is associated with hypothalamic-pituitary-adrenal (HPA) axis responses to psychosocial stress in elderly adults.
METHODS
LTL, measured by qPCR method was available in 1964 women and men from the Helsinki Birth Cohort Study at a mean age of 61.5 (SD=2.9) years. At a mean age of 63.5 (SD=2.7) years a subsample of them took part in the Trier Social Stress Test (TSST) during which salivary cortisol (n=283) and plasma cortisol and ACTH concentrations (n=215) were measured.
RESULTS
Mixed model regression analyses showed no linear or non-linear associations between LTL and HPA axis activity during TSST (p-values for LTL main effects >298; p-values for LTL×time interactions >096). Only one non-linear association between LTL and plasma ACTH area under the curve increment was significant after adjustments for covariates and confounders. This association did not survive correction for multiple testing.
CONCLUSIONS
Our findings suggest that LTL is not consistently associated with HPA axis activity during a standardized psychosocial stress test in elderly adults.
目的
端粒缩短作为细胞衰老的生物标志物，与衰老相关疾病有关。虽然心理压力被认为与端粒缩短过程有关，但与生理应激系统活动的关联仍不明确。我们研究了老年人群中白细胞端粒长度（LTL）是否与下丘脑 - 垂体 - 肾上腺（HPA）轴对心理社会压力的反应相关。
方法
通过qPCR方法测量的LTL数据来自赫尔辛基出生队列研究中的1964名男性和女性，平均年龄为61.5（标准差 = 2.9）岁。在平均年龄63.5（标准差 = 2.7）岁时，其中一个子样本参加了特里尔社会应激测试（TSST），在此期间测量了唾液皮质醇（n = 283）以及血浆皮质醇和促肾上腺皮质激素（ACTH）浓度（n = 215）。
结果
混合模型回归分析显示，在TSST期间，LTL与HPA轴活动之间不存在线性或非线性关联（LTL主效应的p值> 0.298；LTL×时间交互作用的p值> 0.096）。在对协变量和混杂因素进行调整后，仅LTL与曲线下面积增量的血浆ACTH之间的一种非线性关联具有统计学意义。但这种关联在多重检验校正后不再显著。
结论
我们的研究结果表明，在老年人群的标准化心理社会应激测试中，LTL与HPA轴活动之间不存在一致的关联。
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