长链非编码RNA周转
Long noncoding RNA turnover.
作者信息
Yoon Je-Hyun, Kim Jiyoung, Gorospe Myriam
机构信息
Laboratory of Genetics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Laboratory of Genetics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
出版信息
Biochimie. 2015 Oct;117:15-21. doi: 10.1016/j.biochi.2015.03.001. Epub 2015 Mar 10.
Most RNAs transcribed in mammalian cells lack protein-coding sequences. Among them is a vast family of long (>200 nt) noncoding (lnc)RNAs. LncRNAs can modulate cellular protein expression patterns by influencing the transcription of many genes, the post-transcriptional fate of mRNAs and ncRNAs, and the turnover and localization of proteins. Given the broad impact of lncRNAs on gene regulation, there is escalating interest in elucidating the mechanisms that govern the steady-state levels of lncRNAs. In this review, we summarize our current knowledge of the factors and mechanisms that modulate mammalian lncRNA stability.
大多数在哺乳动物细胞中转录的RNA缺乏蛋白质编码序列。其中有一个庞大的长链（>200 nt）非编码（lnc）RNA家族。lncRNAs可以通过影响许多基因的转录、mRNA和ncRNAs的转录后命运以及蛋白质的周转和定位来调节细胞蛋白质表达模式。鉴于lncRNAs对基因调控的广泛影响，人们对阐明控制lncRNAs稳态水平的机制的兴趣与日俱增。在这篇综述中，我们总结了目前关于调节哺乳动物lncRNA稳定性的因素和机制的知识。
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