促进癌细胞存活和生长的代谢途径。
Metabolic pathways promoting cancer cell survival and growth.
作者信息
Boroughs Lindsey K, DeBerardinis Ralph J
机构信息
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA.
1] Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA [2] Department of Pediatrics University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA [3] McDermott Center for Human Growth and Development University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA.
出版信息
Nat Cell Biol. 2015 Apr;17(4):351-9. doi: 10.1038/ncb3124. Epub 2015 Mar 16.
Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.
癌基因的激活和肿瘤抑制因子的缺失促进了癌症中的代谢重编程，导致营养物质摄取增加，以供应能量和生物合成途径。然而，实体瘤内的营养限制可能要求恶性细胞表现出代谢灵活性以维持生长和存活。在这里，我们重点介绍这些适应性机制，并讨论在体内探测肿瘤代谢的新方法及其进一步扩展恶性细胞代谢谱的潜力。
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