通过甲亚胺叶立德与α-亚烷基琥珀酰亚胺的1,3-偶极环加成反应，实现铜催化的双螺吡咯烷骨架的不对称构建。
The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.
作者信息
Yang Wu-Lin, Liu Yang-Zi, Luo Shuai, Yu Xingxin, Fossey John S, Deng Wei-Ping
机构信息
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
出版信息
Chem Commun (Camb). 2015 Jun 4;51(44):9212-5. doi: 10.1039/c5cc02362a.
A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides catalyzed by a novel chiral N,O-ligand/Cu(OAc)2 system is reported, affording dispiropyrrolidine derivatives with spiro quaternary stereogenic centers in good to excellent yields (up to 90%), excellent levels of diastereoselectivities (>20 : 1 dr) and enantioselectivities (up to 97% ee).
报道了一种新型手性N，O-配体/Cu（OAc）₂体系催化的甲亚胺叶立德与α-亚烷基琥珀酰亚胺的高效不对称1,3-偶极环加成反应，得到具有螺季立构中心的双螺吡咯烷衍生物，产率良好至优异（高达90%），非对映选择性（>20:1 dr）和对映选择性（高达97% ee）水平优异。
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