靶向结直肠癌中的成纤维细胞生长因子受体：从实验室到临床

Targeting FGF receptors in colorectal cancer: from bench side to bed side.

作者信息

Abdel-Rahman Omar

出版信息

Future Oncol. 2015;11(9):1373-9. doi: 10.2217/fon.15.38.

DOI:10.2217/fon.15.38

Abstract

Successful management of advanced colorectal cancer has been a challenging job for practicing oncologists as well as a priority for the oncology research community. The better understanding of the underlying patho-biology and critical pathway targets in this disease has contributed to major developments in that direction. In this review, we will revise the different biological and clinical aspects related to the use of FGFR pathway-targeted therapies in advanced colorectal cancer with particular focus on future perspectives in that regard.

摘要

对于执业肿瘤学家而言，成功管理晚期结直肠癌一直是一项具有挑战性的工作，也是肿瘤学研究界的优先事项。对该疾病潜在病理生物学和关键通路靶点的更好理解推动了这方面的重大进展。在本综述中，我们将阐述与晚期结直肠癌中使用FGFR通路靶向治疗相关的不同生物学和临床方面，特别关注这方面的未来前景。