SWI/SNF染色质重塑复合体：其在维持基因组稳定性和预防肿瘤发生中的作用。
The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis.
作者信息
Brownlee Peter M, Meisenberg Cornelia, Downs Jessica A
机构信息
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.
出版信息
DNA Repair (Amst). 2015 Aug;32:127-133. doi: 10.1016/j.dnarep.2015.04.023. Epub 2015 May 1.
Genes encoding subunits of the two SWI/SNF chromatin remodelling complexes (BAF and PBAF) are mutated in almost 20% of all human cancers. In addition to a role in regulating transcription, recent work from our laboratory and others identified roles for both complexes in DNA damage responses and the maintenance of sister chromatid cohesion, which may have profound impacts on genome stability and contribute to its role as a tumour suppressor. Here, we review some of the transcription-independent functions of the SWI/SNF chromatin remodelling complex and discuss these in light of their potential relevance to tumourigenesis.
编码两种SWI/SNF染色质重塑复合物（BAF和PBAF）亚基的基因在几乎20%的人类癌症中发生突变。除了在调节转录中发挥作用外，我们实验室和其他机构最近的研究确定了这两种复合物在DNA损伤反应和姐妹染色单体黏连维持中的作用，这可能对基因组稳定性产生深远影响，并有助于其作为肿瘤抑制因子的作用。在这里，我们综述了SWI/SNF染色质重塑复合物的一些非转录功能，并根据它们与肿瘤发生的潜在相关性进行讨论。
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