对癌症风险“坏运气”解释的批判性审视。
A Critical Examination of the "Bad Luck" Explanation of Cancer Risk.
作者信息
Rozhok Andrii I, Wahl Geoffrey M, DeGregori James
机构信息
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado.
Gene Expression Laboratory, The Salk Institute, La Jolla, CA.
出版信息
Cancer Prev Res (Phila). 2015 Sep;8(9):762-4. doi: 10.1158/1940-6207.CAPR-15-0229. Epub 2015 Jun 29.
Abstract
Tomasetti and Vogelstein (1) argue that lifetime cancer risk for particular tissues is mostly determined by the total number of stem cell (SC) divisions within the tissue, whereby most cancers arise due to "bad luck"—mutations occurring during DNA replication. We argue that the poorly substantiated estimations of SC division parameters and assumptions that oversimplify somatic evolution prevent such a conclusion from being drawn.
摘要
托马塞蒂和沃格尔斯坦（1）认为，特定组织的终生癌症风险主要由该组织内干细胞（SC）分裂的总数决定，据此，大多数癌症是由“坏运气”导致的——即DNA复制过程中发生的突变。我们认为，对SC分裂参数的证据不足的估计以及过度简化体细胞进化的假设阻碍了得出这样的结论。
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