未折叠蛋白反应对蛋白质稳态的调控
Proteostasis control by the unfolded protein response.
作者信息
Hetz Claudio, Chevet Eric, Oakes Scott A
机构信息
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; the Institute of Biomedical Sciences (ICBM), Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile; and in the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
ER440, Oncogenesis, stress and signaling, University of Rennes 1, 35000 Rennes, France; and in the Centre Régional de Lutte Contre le Cancer Eugène Marquis, 35000 Rennes, France.
出版信息
Nat Cell Biol. 2015 Jul;17(7):829-38. doi: 10.1038/ncb3184.
Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed in many physiological and pathological conditions. To cope with endoplasmic reticulum stress, cells activate the unfolded protein response, a dynamic signalling network that orchestrates the recovery of homeostasis or triggers apoptosis, depending on the level of damage. Here we provide an overview of recent insights into the mechanisms that cells employ to maintain proteostasis and how the unfolded protein response determines cell fate under endoplasmic reticulum stress.
在内质网中，错误折叠蛋白质的积累所引发的应激反应在许多生理和病理状况下均可观察到。为应对内质网应激，细胞会激活未折叠蛋白反应，这是一个动态的信号网络，它会根据损伤程度来协调体内平衡的恢复或触发细胞凋亡。在此，我们概述了细胞用于维持蛋白质稳态的机制的最新见解，以及未折叠蛋白反应在内质网应激下如何决定细胞命运。
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