FGF2基因分型变异对骨肉瘤易感性风险的影响：一项病例对照研究。
Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study.
作者信息
Wang Jiefeng, Liu Hongtao, Liu Xiaoyang, Qi Xiaojun
机构信息
Department of Spine Surgery, Yantaiyuhuangding Hospital Shangdong, China.
Department of Joint Surgery, Yantaiyuhuangding Hospital Shangdong, China.
出版信息
Int J Clin Exp Med. 2015 Apr 15;8(4):6114-8. eCollection 2015.
OBJECTIVE
Genetic factors play an important role in osteosarcoma (OS) etiology and fibroblast growth factor 2 (FGF2) gene single polymorphisms may be involved. The aim of this study was to test whether FGF2 variants are associated with susceptibility to OS in a Chinese population.
METHODS
A total of 151 subjects who were diagnosed as OS and 225 healthy age-matched controls were enrolled in the present study. Thers11737764 C/T SNP in FGF2 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs11737764 genotypes and OS susceptibility or severity.
RESULTS
The genotype frequencies of the FGF2 rs11737764 C/T polymorphism were 44.4% (CC), 50.3% (CT) and 5.3% (TT) in OS patients, and 55.6% (CC), 43.1% (CT) and 1.3% (TT) in controls. Rs11737764 C/T was found to be significantly associated with increased risk and OS no matter what genetic model was used.
CONCLUSION
In conclusion, our data demonstrated the FGF2 SNP rs11737764 was significantly associated with increased osteosarcoma susceptibility in Chinese Han Population.
目的
遗传因素在骨肉瘤（OS）病因中起重要作用，成纤维细胞生长因子2（FGF2）基因单核苷酸多态性可能与之相关。本研究旨在检测FGF2基因变异是否与中国人群骨肉瘤易感性相关。
方法
本研究共纳入151例确诊为骨肉瘤的患者和225例年龄匹配的健康对照。对所有受试者的FGF2基因中的rs11737764 C/T单核苷酸多态性进行基因分型。使用SPSS软件研究rs11737764基因型与骨肉瘤易感性或严重程度之间的关联。
结果
骨肉瘤患者中FGF2 rs11737764 C/T多态性的基因型频率为44.4%（CC）、50.3%（CT）和5.3%（TT），对照组中分别为55.6%（CC）、43.1%（CT）和1.3%（TT）。无论采用何种遗传模型，均发现rs11737764 C/T与骨肉瘤风险增加及骨肉瘤显著相关。
结论
总之，我们的数据表明FGF2单核苷酸多态性rs11737764与中国汉族人群骨肉瘤易感性增加显著相关。
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