辅助性T细胞17通过白细胞介素26促进微生物杀伤和对DNA的天然免疫感知。
T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.
作者信息
Meller Stephan, Di Domizio Jeremy, Voo Kui S, Friedrich Heike C, Chamilos Georgios, Ganguly Dipyaman, Conrad Curdin, Gregorio Josh, Le Roy Didier, Roger Thierry, Ladbury John E, Homey Bernhard, Watowich Stanley, Modlin Robert L, Kontoyiannis Dimitrios P, Liu Yong-Jun, Arold Stefan T, Gilliet Michel
机构信息
1] Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] Department of Dermatology, Heinrich-Heine-University Medical Faculty, Düsseldorf, Germany.
Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland.
出版信息
Nat Immunol. 2015 Sep;16(9):970-9. doi: 10.1038/ni.3211. Epub 2015 Jul 13.
Interleukin 17-producing helper T cells (T(H)17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human T(H)17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, T(H)17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of T(H)17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death.
产生白细胞介素17的辅助性T细胞（Th17细胞）在抗感染和介导自身免疫性疾病中起主要作用，但其涉及的机制尚未完全明确。我们发现，白细胞介素26（IL-26），一种源自人类Th17细胞的细胞因子，是一种阳离子两亲性蛋白，可通过形成膜孔杀死细胞外细菌。此外，Th17细胞来源的IL-26与死亡细菌和宿主细胞释放的细菌DNA和自身DNA形成复合物。由此产生的IL-26-DNA复合物通过激活Toll样受体9触发浆细胞样树突状细胞产生I型干扰素，但不依赖于IL-26受体。这些发现通过表明IL-26是一种天然的人类抗菌剂，可促进对细菌和宿主细胞死亡的免疫感知，从而深入了解了Th17细胞的有效抗菌和促炎功能。
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