一项包含肉桂、铬和肌肽的膳食补充剂可降低超重或肥胖糖尿病前期受试者的空腹血糖并增加瘦体重：一项随机、安慰剂对照试验。
A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial.
作者信息
Liu Yuejun, Cotillard Aurélie, Vatier Camille, Bastard Jean-Philippe, Fellahi Soraya, Stévant Marie, Allatif Omran, Langlois Clotilde, Bieuvelet Séverine, Brochot Amandine, Guilbot Angèle, Clément Karine, Rizkalla Salwa W
机构信息
Institute of Cardiometabolism and Nutrition, ICAN, Assistance Publique-Hôpitaux de Paris, Heart and Nutrition Department, Pitié-Salpêtrière Hospital, and Human Nutrition Research Center-Ile de France, 75013, Paris, France; INSERM, UMR S U1166, Nutriomics, 75013, Paris, France; Sorbonne University, Pierre and Marie Curie University, Paris 06, UMR_S 1166 I, Nutriomics Team, Paris, France.
Institute of Cardiometabolism and Nutrition, ICAN, Assistance Publique-Hôpitaux de Paris, Heart and Nutrition Department, Pitié-Salpêtrière Hospital, and Human Nutrition Research Center-Ile de France, 75013, Paris, France; INSERM, UMR S U1166, Nutriomics, 75013, Paris, France.
出版信息
PLoS One. 2015 Sep 25;10(9):e0138646. doi: 10.1371/journal.pone.0138646. eCollection 2015.
BACKGROUND
Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.
OBJECTIVES
Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.
METHODS
In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥ 25 kg/m(2), unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.
RESULTS
Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24 ± 0.50 vs +0.12 ± 0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.
CONCLUSIONS
Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.
TRIAL REGISTRATION
ClinicalTrials.gov NCT01530685.
背景
预防或延缓糖尿病前期进展为糖尿病是一个主要的治疗问题。
目的
我们的目的是评估含肉桂、铬和肌肽的膳食补充剂对中度肥胖或超重糖尿病前期受试者进行4个月治疗的效果，主要结局为空腹血糖（FPG）水平的变化。还评估了血糖稳态、血脂谱、肥胖和炎症标志物的其他参数。
方法
在一项随机、双盲、安慰剂对照研究中，将62名FPG水平在5.55至7 mmol/L之间且体重指数≥25 kg/m²、不愿改变饮食和体育活动习惯的受试者分配接受为期4个月的治疗，分别服用1.2 g/天的膳食补充剂或安慰剂。对患者进行随访直至随机分组后6个月。
结果
与安慰剂相比，膳食补充剂4个月的治疗降低了FPG（分别为-0.24±0.50与+0.12±0.59 mmol/L，p = 0.02），糖化血红蛋白（HbA1c）无明显显著变化。治疗组之间胰岛素敏感性标志物、血浆胰岛素、血脂和炎症标志物无差异。尽管两组之间体重、能量或常量营养素摄入量的变化无显著差异，但与安慰剂相比，膳食补充剂使去脂体重（%）增加（p = 0.02）。基线时FPG水平较高且炎症状态较轻的受试者从膳食补充剂中获益最大。
结论
含肉桂、铬和肌肽的膳食补充剂对超重或肥胖糖尿病前期受试者进行4个月治疗可降低FPG并增加去脂体重。这些有益作用可能为糖尿病预防开辟新途径。
试验注册
ClinicalTrials.gov NCT01530685。
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