Siregar Adiatma Y M, Tromp Noor, Komarudin Dindin, Wisaksana Rudi, van Crevel Reinout, van der Ven Andre, Baltussen Rob
Integrated Management for Prevention and Control and Treatment of HIV/AIDS (IMPACT), Bandung, Indonesia.
Department of Economics, Faculty of Economics and Business, Padjadjaran University, Bandung, Indonesia.
BMC Health Serv Res. 2015 Sep 30;15:440. doi: 10.1186/s12913-015-1098-3.
We report an economic analysis of Human Immunodeficiency Virus (HIV) care and treatment in Indonesia to assess the options and limitations of costs reduction, improving access, and scaling up services.
We calculated the cost of providing HIV care and treatment in a main referral hospital in West Java, Indonesia from 2008 to 2010, differentiated by initiation of treatment at different CD4 cell count levels (0-50, 50-100, 100-150, 150-200, and >200 cells/mm(3)); time of treatment; HIV care and opportunistic infections cost components; and the costs of patients for seeking and undergoing care.
Before antiretroviral treatment (ART) initiation, costs were dominated by laboratory tests (>65 %), and after initiation, by antiretroviral drugs (≥60 %). Average treatment costs per patient decreased with time on treatment (e.g. from US$580 per patient in the first 6 month to US$473 per patient in months 19-24 for those with CD4 cell counts under 50 cells/mm(3)). Higher CD4 cell counts at initiation resulted in lower laboratory and opportunistic infection treatment costs. Transportation cost dominated the costs of patients for seeking and undergoing care (>40 %).
Costs of providing ART are highest during the early phase of treatment. Costs reductions can potentially be realized by early treatment initiation and applying alternative laboratory tests with caution. Scaling up ART at the community level in certain high prevalence settings may improve early uptake, adherence, and reduce transportation costs.
我们报告了印度尼西亚人类免疫缺陷病毒(HIV)护理与治疗的经济分析,以评估降低成本、改善可及性及扩大服务的选择与局限性。
我们计算了2008年至2010年印度尼西亚西爪哇一家主要转诊医院提供HIV护理与治疗的成本,按不同CD4细胞计数水平(0 - 50、50 - 100、100 - 150、150 - 200及>200个细胞/mm³)开始治疗、治疗时间、HIV护理及机会性感染成本构成以及患者寻求和接受护理的成本进行区分。
在开始抗逆转录病毒治疗(ART)之前,成本主要由实验室检查主导(>65%),开始治疗后则由抗逆转录病毒药物主导(≥60%)。每位患者的平均治疗成本随治疗时间下降(例如,对于CD4细胞计数低于50个细胞/mm³的患者,从最初6个月的每位患者580美元降至第19 - 24个月的每位患者473美元)。开始治疗时较高的CD4细胞计数导致较低的实验室及机会性感染治疗成本。交通成本在患者寻求和接受护理的成本中占主导(>40%)。
提供ART的成本在治疗早期最高。通过尽早开始治疗及谨慎应用替代实验室检查可能实现成本降低。在某些高流行地区的社区层面扩大ART规模可能会提高早期接受度、依从性并降低交通成本。