重组腐皮镰孢菌和主要为克隆型的瓶霉属物种推动了人类着色芽生菌病的全球传播。
Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species.
作者信息
Deng Shuwen, Tsui Clement K M, Gerrits van den Ende A H G, Yang Liyue, Najafzadeh Mohammad Javad, Badali Hamid, Li Ruoyu, Hagen Ferry, Meis Jacques F, Sun Jiufeng, Dolatabadi Somayeh, Papierok Bernard, Pan Weihua, de Hoog G S, Liao Wanqing
机构信息
Shanghai Institute of Medical Mycology, Changzheng Hospital, Shanghai, China; First Hospital of Xinjiang Medical University, Xinjiang, China; CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
British Columbia Public Health Microbiology & Reference Laboratory at BCCDC site, Provincial Health Services Authority, Vancouver, Canada.
出版信息
PLoS Negl Trop Dis. 2015 Oct 23;9(10):e0004004. doi: 10.1371/journal.pntd.0004004. eCollection 2015.
Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carrionii strains and 60 strains of three Fonsecaea species were analyzed for rDNA ITS, partial β-tubulin, and amplified fragment-length polymorphism (AFLP) fingerprints. Populations differed significantly between continents. Lowest haplotype diversity was found in South American populations, while African strains were the most diverse. Gene flow was noted between the African population and all other continents. The general pattern of Fonsecaea agents of chromoblastomycosis differed significantly from that of C. carrionii and revealed deeper divergence among three differentiated species with smaller numbers of haplotypes, indicating a longer evolutionary history.
将非洲、亚洲、澳大利亚、中美洲和南美洲干旱气候地区人类着色芽生菌病病原体卡里翁枝孢霉（Cladophialophora carrionii）的全球分布模式，与热带雨林地区该病病原体替代菌属——丰塞卡菌属（Fonsecaea spp.）的类似数据进行了比较。对73株卡里翁枝孢霉菌株以及3种丰塞卡菌属的60个菌株进行了群体多样性分析，分析内容包括核糖体DNA内转录间隔区（rDNA ITS）、部分β微管蛋白以及扩增片段长度多态性（AFLP）指纹图谱。各大洲之间的群体存在显著差异。南美群体的单倍型多样性最低，而非洲菌株的多样性最高。非洲群体与所有其他大陆之间均存在基因流动。着色芽生菌病的丰塞卡菌属病原体总体分布模式与卡里翁枝孢霉显著不同，并且在三种分化物种之间显示出更大的差异，单倍型数量较少，这表明其进化历史更长。
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