循环肿瘤细胞和循环肿瘤 DNA：临床应用之路上的挑战与机遇。

Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility.

机构信息

Department of Medical Oncology and Breast Cancer Translational Research Laboratory J. C. Heuson, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Google[x] Life Sciences, Google, Inc, Mountain View, California.

出版信息

Clin Cancer Res. 2015 Nov 1;21(21):4786-800. doi: 10.1158/1078-0432.CCR-14-1190.

DOI:10.1158/1078-0432.CCR-14-1190

PMID:26527805

Abstract

Recent technological advances have enabled the detection and detailed characterization of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) in blood samples from patients with cancer. Often referred to as a "liquid biopsy," CTCs and ctDNA are expected to provide real-time monitoring of tumor evolution and therapeutic efficacy, with the potential for improved cancer diagnosis and treatment. In this review, we focus on these opportunities as well as the challenges that should be addressed so that these tools may eventually be implemented into routine clinical care.

摘要

最近的技术进步使得能够在癌症患者的血液样本中检测和详细分析循环肿瘤细胞（CTC）和循环肿瘤 DNA（ctDNA）。这些通常被称为“液体活检”的 CTC 和 ctDNA 有望实时监测肿瘤的演变和治疗效果，具有改善癌症诊断和治疗的潜力。在这篇综述中，我们关注这些机会以及应该解决的挑战，以便这些工具最终能够被纳入常规临床护理。