Parada Carolina, Chai Yang
Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA.
Curr Top Dev Biol. 2015;115:31-58. doi: 10.1016/bs.ctdb.2015.07.023. Epub 2015 Oct 1.
The tongue and mandible have common origins. They arise simultaneously from the mandibular arch and are coordinated in their development and growth, which is evident from several clinical conditions such as Pierre Robin sequence. Here, we review in detail the molecular networks controlling both mandible and tongue development. We also discuss their mechanical relationship and evolution as well as the potential for stem cell-based therapies for disorders affecting these organs.
舌与下颌骨有共同的起源。它们同时起源于下颌弓,在发育和生长过程中相互协调,这在一些临床病症如皮埃尔·罗宾序列征中很明显。在此,我们详细综述控制下颌骨和舌发育的分子网络。我们还讨论它们的力学关系和进化,以及针对影响这些器官的疾病基于干细胞疗法的潜力。