喀麦隆民间医学中使用的12种植物甲醇提取物的抗金黄色葡萄球菌活性。
Anti-Staphylococcus aureus activity of methanol extracts of 12 plants used in Cameroonian folk medicine.
作者信息
Sama Fonkeng Leonard, Mouokeu Raymond Simplice, Tume Christopher, Njateng Guy Sedar Singor, Kamcthueng Monique Odette, Ndonkou Nfozon Jinette, Kuiate Jules-Roger
机构信息
Laboratory of Microbiology and Antimicrobial Substances, Faculty of Science, P.O. Box 67, Dschang, Cameroon.
Institute of Fisheries and Aquatic Sciences, University of Douala, P.O. Box 7236, Douala, Cameroon.
出版信息
BMC Res Notes. 2015 Nov 24;8:710. doi: 10.1186/s13104-015-1663-1.
BACKGROUND
The emergence of bacterial infections including those associated with Staphylococcus aureus causes a benefit of interest to medicinal plants as an effective means of control. The present study was designed to investigate the activities of 12 selected Cameroonian medicinal plants against S. aureus isolates.
METHODS
The plant extracts were prepared by maceration in methanol at laboratory temperature. Qualitative phytochemical analysis was performed by chemical reaction methods. The broth microdilution method was used to evaluate the activities of plant extracts against 11 S. aureus clinical isolates.
RESULTS
Dacryodes edulis was found to have significant antibacterial activity on all the S. aureus isolates (MIC = 64-256 µg/ml). Occimum gratissimum revealed significant inhibitory activity on 9 of the 11 isolates while Commelina erecta and Spilanthes filicaulis revealed similar results on 6 of the 11 clinical isolates.
CONCLUSION
The present findings showed that D. eduli, O. gratissimum, C. erecta and S. filicaulis possess interesting inhibitory properties against S. aureus species. These plants could therefore be good candidates to overcome infectious diseases associated with these microorganisms.
背景
包括与金黄色葡萄球菌相关的细菌感染的出现，使得药用植物作为一种有效的控制手段受到关注。本研究旨在调查12种选定的喀麦隆药用植物对金黄色葡萄球菌分离株的活性。
方法
在实验室温度下，通过甲醇浸渍制备植物提取物。采用化学反应方法进行定性植物化学分析。采用肉汤微量稀释法评估植物提取物对11株金黄色葡萄球菌临床分离株的活性。
结果
发现可食油桃木对所有金黄色葡萄球菌分离株均具有显著的抗菌活性（最低抑菌浓度=64-256微克/毫升）。九层塔对11株分离株中的9株显示出显著的抑制活性，而直立鸭跖草和丝状金纽扣对11株临床分离株中的6株显示出相似的结果。
结论
目前的研究结果表明，可食油桃木、九层塔、直立鸭跖草和丝状金纽扣对金黄色葡萄球菌具有有趣的抑制特性。因此，这些植物可能是克服与这些微生物相关的传染病的良好候选植物。
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