肾素前体在体内平衡和疾病中的新功能。
Novel Functions of Renin Precursors in Homeostasis and Disease.
作者信息
Gomez R Ariel, Sequeira-Lopez Maria Luisa S
机构信息
University of Virginia School of Medicine, Child Health Research Center, Charlottesville, Virginia
出版信息
Physiology (Bethesda). 2016 Jan;31(1):25-33. doi: 10.1152/physiol.00039.2015.
Abstract
Renin progenitors appear early and are found in multiple tissues throughout the embryo. Besides their well known role in blood pressure and fluid homeostasis, renin progenitors participate in tissue morphogenesis, repair, and regeneration, and may integrate immune and endocrine responses. In the bone marrow, renin cells offer clues to understand normal and neoplastic hematopoiesis.
摘要
肾素祖细胞出现较早，在胚胎期的多个组织中均可发现。除了在血压和液体稳态中广为人知的作用外，肾素祖细胞还参与组织形态发生、修复和再生，并且可能整合免疫和内分泌反应。在骨髓中，肾素细胞为理解正常和肿瘤性造血提供了线索。
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本文引用的文献
1
Vascular versus tubular renin: role in kidney development.
Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7. doi: 10.1152/ajpregu.00313.2015. Epub 2015 Aug 5.
2
Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium.
Am J Physiol Renal Physiol. 2015 Sep 15;309(6):F531-9. doi: 10.1152/ajprenal.00247.2015. Epub 2015 Jul 22.
3
Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling.
Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R576-84. doi: 10.1152/ajpregu.00222.2015. Epub 2015 Jul 15.
4
Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4.
Hypertension. 2015 May;65(5):1047-54. doi: 10.1161/HYPERTENSIONAHA.114.04611. Epub 2015 Mar 16.
5
The earliest metanephric arteriolar progenitors and their role in kidney vascular development.
Am J Physiol Regul Integr Comp Physiol. 2015 Jan 15;308(2):R138-49. doi: 10.1152/ajpregu.00428.2014. Epub 2014 Nov 26.
6
Renin lineage cells repopulate the glomerular mesangium after injury.
J Am Soc Nephrol. 2015 Jan;26(1):48-54. doi: 10.1681/ASN.2014030265. Epub 2014 Jun 5.
7
Recombination signal binding protein for Ig-κJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic gene expression.
J Am Soc Nephrol. 2015 Jan;26(1):67-80. doi: 10.1681/ASN.2013101045. Epub 2014 Jun 5.
8
Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia.
Nat Commun. 2014;5:3273. doi: 10.1038/ncomms4273.
9
Pericytes synthesize renin.
World J Nephrol. 2013 Feb 6;2(1):11-6. doi: 10.5527/wjn.v2.i1.11.
10
Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease.
Am J Pathol. 2013 Aug;183(2):542-57. doi: 10.1016/j.ajpath.2013.04.024. Epub 2013 Jun 14.
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