酵母模型系统中的锌感知与调控
Zinc sensing and regulation in yeast model systems.
作者信息
Wilson Stevin, Bird Amanda J
机构信息
Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA.
Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Arch Biochem Biophys. 2016 Dec 1;611:30-36. doi: 10.1016/j.abb.2016.02.031. Epub 2016 Mar 3.
Abstract
The Zap1 transcription factor of Saccharomyces cerevisiae and the Loz1 transcription factor of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling the expression of genes necessary for zinc metabolism. Zap1 activates gene expression when cells are limited for zinc, while Loz1 is required for gene repression when zinc is in excess. In this review we highlight what is known about the underlying mechanisms by which these factors are regulated by zinc, and how transcriptional activation and repression in eukaryotic cells can be finely tuned according to intracellular zinc availability.
摘要
酿酒酵母的Zap1转录因子和粟酒裂殖酵母的Loz1转录因子，通过控制锌代谢所需基因的表达，在锌稳态中都起着核心作用。当细胞锌含量有限时，Zap1激活基因表达，而当锌过量时，Loz1则是基因抑制所必需的。在这篇综述中，我们重点介绍了关于这些因子如何受锌调控的潜在机制，以及真核细胞中的转录激活和抑制如何根据细胞内锌的可利用性进行精细调节的已知信息。
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