胰腺癌中miRNA基因信号通路的进展
Developments in miRNA gene signaling pathways in pancreatic cancer.
作者信息
Vorvis Christina, Koutsioumpa Marina, Iliopoulos Dimitrios
机构信息
Center for Systems Biomedicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
出版信息
Future Oncol. 2016 May;12(9):1135-50. doi: 10.2217/fon-2015-0050. Epub 2016 Mar 17.
Abstract
Pancreatic cancer is a devastating malignancy that ranks as the fourth leading cause of cancer-related deaths worldwide. Dismal prognosis is mainly attributable to limited knowledge of the molecular pathogenesis of the disease. miRNAs have been found to be deregulated in pancreatic cancer, affecting several steps of initiation and aggressiveness of the disease by regulating important signaling pathways, such as the KRAS and Notch pathways. Moreover, the effect of miRNAs on regulating cell cycle events and expression of transcription factors has gained a lot of attention. Recent studies have highlighted the application of miRNAs as biomarkers and therapeutic tools. The current review focuses on latest advances with respect to the roles of miRNAs in pancreatic ductal adenocarcinoma associated signaling pathways and miRNA-based therapeutics.
摘要
胰腺癌是一种极具毁灭性的恶性肿瘤，在全球癌症相关死亡原因中位列第四。预后不佳主要归因于对该疾病分子发病机制的了解有限。已发现miRNA在胰腺癌中表达失调，通过调节重要信号通路（如KRAS和Notch通路）影响疾病起始和侵袭的多个步骤。此外，miRNA对细胞周期事件和转录因子表达的调节作用已备受关注。最近的研究突出了miRNA作为生物标志物和治疗工具的应用。本综述聚焦于miRNA在胰腺导管腺癌相关信号通路中的作用以及基于miRNA的治疗方法的最新进展。
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