miR-454过表达与肝细胞癌预后不良有关。
Involvement of miR-454 overexpression in the poor prognosis of hepatocellular carcinoma.
作者信息
Zhou L, Qu Y-M, Zhao X-M, Yue Z-D
机构信息
Departmemt of Oncology, PLA General Hospital, Peking, China.
出版信息
Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):825-9.
OBJECTIVE
Many studies informed that microRNAs (miRNAs) could function as diagnostic and prognostic indicators in several cancers. The prognostic value of miR-454 in hepatocellular carcinoma has not been investigated.
PATIENTS AND METHODS
A total of 265 patients with HCC were obtained in this retrospective study between June 2009 and July 2014. qPCR was conducted to evaluate the expressed amount of the miR-454. The Kaplan-Meier method was conducted to explore the survival status of HCC patients. The log-rank test was used to analyze differences in survival rates.
RESULTS
The expression of miR-454 was significantly upregulated in HCC tissues compared with adjacent non-cancerous tissues (p < 0.001). High levels of miR-454 in HCC tissues were correlated with a low 5-year overall survival (OS) (p < 0.001). Moreover, patients with high miR-454 expression had decreased disease-free survival (DFS) (p < 0.001). Furthermore, multivariate analysis showed that up-regulation of miR-454 was an independent prognostic factor for both 5-year OS (p = 0.013) and 5-year DFS (p = 0.008).
CONCLUSIONS
We firstly prove that expression of miR-454 may be a novel and valuable prognostic factor in HCC.
目的
许多研究表明，微小RNA（miRNA）可作为多种癌症的诊断和预后指标。miR-454在肝细胞癌中的预后价值尚未得到研究。
患者与方法
本回顾性研究共纳入2009年6月至2014年7月期间的265例肝细胞癌患者。采用qPCR检测miR-454的表达量。采用Kaplan-Meier法探讨肝细胞癌患者的生存状况。采用对数秩检验分析生存率的差异。
结果
与癌旁非癌组织相比，miR-454在肝细胞癌组织中的表达显著上调（p<0.001）。肝细胞癌组织中miR-454高水平与5年总生存率（OS）低相关（p<0.001）。此外，miR-454高表达患者的无病生存期（DFS）降低（p<0.001）。此外，多因素分析显示，miR-454上调是5年OS（p=0.013）和5年DFS（p=0.008）的独立预后因素。
结论
我们首次证明，miR-454的表达可能是肝细胞癌一种新的有价值的预后因素。
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