靶向肿瘤中异常的内质网应激反应：癌症免疫治疗的新方法。
Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy.
作者信息
Cubillos-Ruiz Juan R, Glimcher Laurie H
机构信息
Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.
Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
出版信息
Oncoimmunology. 2015 Oct 29;5(3):e1098802. doi: 10.1080/2162402X.2015.1098802. eCollection 2016 Mar.
Abstract
Cancers thrive under adverse conditions and simultaneously inhibit antitumor immunity. We recently found that endoplasmic reticulum (ER) stress responses driven by the IRE1α-XBP1 pathway not only promote cancer cell survival, but also provoke severe dendritic cell (DC) dysfunction in tumors. Targeting IRE1α-XBP1 represents a two-pronged approach to restrain malignant cells while eliciting concomitant antitumor immunity.
摘要
癌症在不利条件下茁壮成长，同时抑制抗肿瘤免疫。我们最近发现，由IRE1α-XBP1途径驱动的内质网（ER）应激反应不仅促进癌细胞存活，还会引发肿瘤中严重的树突状细胞（DC）功能障碍。靶向IRE1α-XBP1是一种双管齐下的方法，既能抑制恶性细胞，又能引发伴随的抗肿瘤免疫。
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