脂联素、瘦素和脂肪酸通过脂肪组织串扰维持代谢稳态
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.
作者信息
Stern Jennifer H, Rutkowski Joseph M, Scherer Philipp E
机构信息
Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Cell Metab. 2016 May 10;23(5):770-84. doi: 10.1016/j.cmet.2016.04.011.
Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions, and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis, highlighting three critical mediators: adiponectin, leptin, and fatty acids.
在过去几十年里，代谢研究在确立脂肪细胞作为全身营养和能量稳态调节中的核心调节器方面取得了巨大进展。脂肪细胞在多个控制层面发挥作用，与各器官系统进行沟通，以调节基因表达、糖调节激素的胞吐作用、酶促反应和营养物质通量，从而平衡正能量或负能量平衡下的代谢需求。对这些机制的识别具有极大潜力，可为糖尿病及相关代谢紊乱的治疗确定新靶点。在此，我们综述脂肪细胞在维持代谢稳态中的核心作用，重点介绍三种关键介质：脂联素、瘦素和脂肪酸。
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