Genetics of systemic lupus erythematosus and Sjögren's syndrome: an update.

PURPOSE OF REVIEW

To describe the recent studies on the genetics of systemic lupus erythematosus (SLE) and Sjögren's syndrome.

RECENT FINDINGS

We overview the most recent findings on the genetic susceptibility of the diseases and provide information on their genetic similarities and differences.

SUMMARY

SLE and Sjögren's syndrome are two closely related systemic autoimmune diseases that share multiple clinical and molecular aspects, including a significant number of susceptibility genes. Several genome-wide association studies were recently published in different populations that provide a better picture of their molecular mechanisms. It is becoming clear that their genetic architecture is quite well established, but more information is required on expression quantitative trait loci, epigenetic genome-wide analyses, gene × gene interactions and the role of rare variants.