线粒体相关内质网膜上的致癌和抑癌信号转导
Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes.
作者信息
Marchi Saverio, Giorgi Carlotta, Oparka Monika, Duszynski Jerzy, Wieckowski Mariusz R, Pinton Paolo
机构信息
Department of Morphology; Surgery and Experimental Medicine ; Section of Pathology; Oncology and Experimental Biology and LTTA Center ; University of Ferrara ; Ferrara, Italy.
Department of Biochemistry; Nencki Institute of Experimental Biology ; Warsaw, Poland.
出版信息
Mol Cell Oncol. 2014 Oct 29;1(2):e956469. doi: 10.4161/23723548.2014.956469. eCollection 2014 Apr-Jun.
Abstract
The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activities of several proapoptotic and antiapoptotic factors. Here, we review the function of the endoplasmic reticulum-mitochondria interface as a primary platform for decoding danger signals as well as a structural accommodation for several regulator or effector proteins.
摘要
原癌基因和肿瘤抑制因子用于调节细胞死亡途径的不同机制与其定位密切相关。除了在转录/核水平对细胞凋亡进行经典调控外，细胞内区域正成为几种促凋亡和抗凋亡因子发挥作用的关键位点。在此，我们综述内质网-线粒体界面的功能，它是解码危险信号的主要平台，也是几种调节蛋白或效应蛋白的结构容纳场所。
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