尿素循环与癌细胞增殖之间的代谢联系。
A metabolic link between the urea cycle and cancer cell proliferation.
作者信息
Nagamani Sandesh C S, Erez Ayelet
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Houston, TX, USA.
Department of Biological Regulation, Weizmann Institute of Science , Rehovot, Israel.
出版信息
Mol Cell Oncol. 2016 Feb 18;3(2):e1127314. doi: 10.1080/23723556.2015.1127314. eCollection 2016 Mar.
Abstract
Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.
摘要
I型瓜氨酸血症是一种先天性代谢紊乱疾病，临床观察结果促使我们探索在癌症中进行体细胞ASS1基因沉默的益处。我们发现，ASS1的下调会导致其底物天冬氨酸优先用于嘧啶合成以支持细胞增殖。减少用于嘧啶合成的天冬氨酸供应会限制癌细胞的增殖。
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本文引用的文献
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