CDKN2A（p16（INK4a））的遗传和表观遗传改变在癌症中的意义。
Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer.
机构信息
China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, Zhengzhou, Henan 450008, China.
Department of Pharmaceutical Science and Engineering, Seowon University, Cheongju 361-742, South Korea.
出版信息
EBioMedicine. 2016 Jun;8:30-39. doi: 10.1016/j.ebiom.2016.04.017. Epub 2016 May 3.
Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, has a causal link with several different types of cancers. The p16(INK4a) protein plays an executional role in cell cycle and senescence through the regulation of the cyclin-dependent kinase (CDK) 4/6 and cyclin D complexes. Several genetic and epigenetic aberrations of CDKN2A lead to enhanced tumorigenesis and metastasis with recurrence of cancer and poor prognosis. In these cases, the restoration of genetic and epigenetic reactivation of CDKN2A is a practical approach for the prevention and therapy of cancer. This review highlights the genetic status of CDKN2A as a prognostic and predictive biomarker in various cancers.
基因异常沉默与癌症发生过程中的细胞周期调控改变密切相关。特别是，编码 p16(INK4a) 蛋白的抑癌基因 CDKN2A 的沉默与多种不同类型的癌症有关。p16(INK4a) 蛋白通过调节细胞周期蛋白依赖性激酶 (CDK) 4/6 和细胞周期蛋白 D 复合物在细胞周期和衰老中发挥执行作用。CDKN2A 的几种遗传和表观遗传异常导致肿瘤发生和转移增强，癌症复发和预后不良。在这些情况下，恢复 CDKN2A 的遗传和表观遗传重新激活是预防和治疗癌症的一种实用方法。本综述强调了 CDKN2A 的遗传状态作为各种癌症的预后和预测生物标志物。
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