鞘脂类作为真菌感染治疗的靶点。
Sphingolipids as targets for treatment of fungal infections.
作者信息
Rollin-Pinheiro Rodrigo, Singh Ashutosh, Barreto-Bergter Eliana, Del Poeta Maurizio
机构信息
Departamento de Microbiologia Geral, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, UFRJ, 21941-902 Rio de Janeiro, Brazil.
Department of Molecular Genetics & Microbiology, Stony Brook University, 145 Life Sciences Building, Stony Brook, 11794 NY, USA.
出版信息
Future Med Chem. 2016 Aug;8(12):1469-84. doi: 10.4155/fmc-2016-0053. Epub 2016 Aug 9.
Invasive fungal infections have significantly increased in the last few decades. Three classes of drugs are commonly used to treat these infections: polyenes, azoles and echinocandins. Unfortunately each of these drugs has drawbacks; polyenes are toxic, resistance against azoles is emerging and echinocandins have narrow spectrum of activity. Thus, the development of new antifungals is urgently needed. In this context, fungal sphingolipids have emerged as a potential target for new antifungals, because their biosynthesis in fungi is structurally different than in mammals. Besides, some fungal sphingolipids play an important role in the regulation of virulence in a variety of fungi. This review aims to highlight the diverse strategies that could be used to block the synthesis or/and function of fungal sphingolipids.
在过去几十年中，侵袭性真菌感染显著增加。通常使用三类药物来治疗这些感染：多烯类、唑类和棘白菌素类。不幸的是，这些药物都有缺点；多烯类有毒，对唑类的耐药性正在出现，而棘白菌素类的活性谱较窄。因此，迫切需要开发新的抗真菌药物。在这种背景下，真菌鞘脂已成为新抗真菌药物的潜在靶点，因为它们在真菌中的生物合成在结构上与哺乳动物不同。此外，一些真菌鞘脂在多种真菌的毒力调节中起重要作用。本综述旨在强调可用于阻断真菌鞘脂合成或/和功能的多种策略。
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