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基于人群的胆囊良性疾病行胆囊切除术的结局的队列研究。

Population-based cohort study of outcomes following cholecystectomy for benign gallbladder diseases.

出版信息

Br J Surg. 2016 Nov;103(12):1704-1715. doi: 10.1002/bjs.10287. Epub 2016 Aug 26.

Abstract

BACKGROUND

The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all-cause 30-day readmissions and complications in a prospective population-based cohort.

METHODS

Data were collected on consecutive patients undergoing cholecystectomy in acute UK and Irish hospitals between 1 March and 1 May 2014. Potential explanatory variables influencing all-cause 30-day readmissions and complications were analysed by means of multilevel, multivariable logistic regression modelling using a two-level hierarchical structure with patients (level 1) nested within hospitals (level 2).

RESULTS

Data were collected on 8909 patients undergoing cholecystectomy from 167 hospitals. Some 1451 cholecystectomies (16·3 per cent) were performed as an emergency, 4165 (46·8 per cent) as elective operations, and 3293 patients (37·0 per cent) had had at least one previous emergency admission, but had surgery on a delayed basis. The readmission and complication rates at 30 days were 7·1 per cent (633 of 8909) and 10·8 per cent (962 of 8909) respectively. Both readmissions and complications were independently associated with increasing ASA fitness grade, duration of surgery, and increasing numbers of emergency admissions with gallbladder disease before cholecystectomy. No identifiable hospital characteristics were linked to readmissions and complications.

CONCLUSION

Readmissions and complications following cholecystectomy are common and associated with patient and disease characteristics.

摘要

背景

本研究旨在描述良性胆囊疾病的治疗方法,并确定与胆囊切除术后 30 天内所有原因再入院和并发症相关的特征。

方法

本研究数据来自于 2014 年 3 月 1 日至 5 月 1 日期间,在英国和爱尔兰的急性医院中连续进行胆囊切除术的患者。通过使用具有两级分层结构的多级、多变量逻辑回归模型,分析影响所有原因 30 天内再入院和并发症的潜在解释变量,其中患者(一级)嵌套在医院(二级)内。

结果

共纳入了 167 家医院的 8909 例胆囊切除术患者。其中 1451 例(16.3%)为紧急手术,4165 例(46.8%)为择期手术,3293 例(37.0%)至少有一次先前的紧急入院史,但手术时间有所延迟。术后 30 天的再入院率和并发症发生率分别为 7.1%(633/8909)和 10.8%(962/8909)。再入院和并发症均与 ASA 体能分级增加、手术持续时间延长以及在胆囊切除术前有更多次因胆囊疾病而紧急入院有关。没有可识别的医院特征与再入院和并发症相关。

结论

胆囊切除术后的再入院和并发症较为常见,与患者和疾病特征有关。

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