成年男性和女性癌症风险的早期起源：童年不幸的影响？
Early Origins of Adult Cancer Risk Among Men and Women: Influence of Childhood Misfortune?
作者信息
Kemp Blakelee R, Ferraro Kenneth F, Morton Patricia M, Mustillo Sarah A
机构信息
1 Purdue University, West Lafayette, IN, USA.
2 Rice University, Houston, TX, USA.
出版信息
J Aging Health. 2018 Jan;30(1):140-163. doi: 10.1177/0898264316670049. Epub 2016 Sep 27.
OBJECTIVE
To examine the effect of five childhood misfortune domains-parental behavior, socioeconomic status, infectious diseases, chronic diseases, and impairments-on all-site and selected site-specific cancer prevalence and all-site cancer incidence.
METHOD
Panel data from the Health and Retirement Study (2004-2012) were used to investigate cancer risk among adults above the age of 50.
RESULTS
Risky parental behavior and impairment in childhood were associated with higher odds of all-site cancer prevalence, and childhood chronic disease was associated with prostate cancer, even after adjusting for adult health and socioeconomic factors. Moreover, having one infectious disease in childhood lowered the odds of colon cancer. Cancer trends varied by race and ethnicity, most notably, higher prostate cancer prevalence among Black men and lower all-site cancer among Hispanic adults.
DISCUSSION
These findings underscore the importance of examining multiple domains of misfortune because the type and amount of misfortune influence cancer risk in different ways.
目的
研究童年时期五个不幸领域——父母行为、社会经济地位、传染病、慢性病和残疾——对所有部位及特定部位癌症患病率以及所有部位癌症发病率的影响。
方法
利用健康与退休研究（2004 - 2012年）的面板数据调查50岁以上成年人的癌症风险。
结果
即使在对成人健康和社会经济因素进行调整之后，童年时期危险的父母行为和残疾与所有部位癌症患病率的较高几率相关，童年慢性病与前列腺癌相关。此外，童年时期患有一种传染病会降低患结肠癌的几率。癌症趋势因种族和族裔而异，最显著的是，黑人男性前列腺癌患病率较高，西班牙裔成年人所有部位癌症患病率较低。
讨论
这些发现强调了研究多个不幸领域的重要性，因为不幸的类型和程度以不同方式影响癌症风险。
Zotero 插件