2016年约翰·J·阿贝尔奖讲座：靶向癌症中的机械微环境
The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer.
作者信息
Majeski Hannah E, Yang Jing
机构信息
Department of Pharmacology (H.E.M., J.Y.), Department of Pediatrics (J.Y.), and Biomedical Sciences Graduate Program (H.E.M., J.Y.), Moores Cancer Center, University of California, San Diego, La Jolla, California.
Department of Pharmacology (H.E.M., J.Y.), Department of Pediatrics (J.Y.), and Biomedical Sciences Graduate Program (H.E.M., J.Y.), Moores Cancer Center, University of California, San Diego, La Jolla, California
出版信息
Mol Pharmacol. 2016 Dec;90(6):744-754. doi: 10.1124/mol.116.106765. Epub 2016 Oct 14.
Past decades of cancer research have mainly focused on the role of various extracellular and intracellular biochemical signals on cancer progression and metastasis. Recent studies suggest an important role of mechanical forces in regulating cellular behaviors. This review first provides an overview of the mechanobiology research field. Then we specially focus on mechanotransduction pathways in cancer progression and describe in detail the key signaling components of such mechanotransduction pathways and extracellular matrix components that are altered in cancer. Although our understanding of mechanoregulation in cancer is still in its infancy, some agents against key mechanoregulators have been developed and will be discussed to explore the potential of pharmacologically targeting mechanotransduction in cancer.
过去几十年的癌症研究主要集中在各种细胞外和细胞内生化信号在癌症进展和转移中的作用。最近的研究表明机械力在调节细胞行为中起着重要作用。本综述首先概述了力学生物学研究领域。然后我们特别关注癌症进展中的机械转导途径，并详细描述这些机械转导途径的关键信号成分以及在癌症中发生改变的细胞外基质成分。尽管我们对癌症中机械调节的理解仍处于起步阶段，但已经开发出一些针对关键机械调节因子的药物，并将进行讨论，以探索在癌症中对机械转导进行药理学靶向治疗的潜力。
Zotero 插件